The Role of l Carnitine in Mitochondria, Prevention of Metabolic Inflexibility and Disease Initiation Carnitine Shuttle an overview ScienceDirect Topics Role of Carnitine Shuttle System in the Active Transport of Fatty Acyl Coa into the mitochondrial L Carnitine helps shuttle fatty acids into the mitochondria (the power plants of your cells) where they can be burned for energy. It's often used in fat metabolism and energy support formulas.